Toxoplasma gondii Strategy for Intracellular Survival: Is it Still Enigmatic?
نویسندگان
چکیده
منابع مشابه
Paclitaxel arrests growth of intracellular Toxoplasma gondii.
Addition of paclitaxel (Taxol) at a concentration of 1 microM to Toxoplasma gondii-infected human foreskin fibroblasts arrested parasite multiplication. Division of the T. gondii tachyzoite nucleus was inhibited, leading to syncytium-like parasite structures within the fibroblasts by 24 h after infection and treatment of the cultures. By 4 days after infection and treatment of the cultures with...
متن کاملA CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii
Cytidine triphosphate synthase catalyzes the synthesis of cytidine 5'-triphosphate (CTP) from uridine 5'-triphosphate (UTP), the final step in the production of cytidine nucleotides. CTP synthases also form filamentous structures of different morphologies known as cytoophidia, whose functions in most organisms are unknown. Here, we identified and characterized a novel CTP synthase (TgCTPS) from...
متن کاملMicroneme rhomboid protease TgROM1 is required for efficient intracellular growth of Toxoplasma gondii.
Rhomboids are serine proteases that cleave their substrates within the transmembrane domain. Toxoplasma gondii contains six rhomboids that are expressed in different life cycle stages and localized to different cellular compartments. Toxoplasma rhomboid protein 1 (TgROM1) has previously been shown to be active in vitro, and the orthologue in Plasmodium falciparum processes the essential microne...
متن کاملToxoplasma gondii: inhibition of the intracellular growth by human lactoferrin.
In the present paper we focused on the potential role of human lactoferrin for the intracellular replication rate of T. gondii BK tachyzoites following our earlier observation that Toxoplasma gondii was able to bind human lactoferrin but not serum transferrin. The study was performed in vitro on human CaCo-2 epithelial cells and mouse L929 fibroblasts. We found that the multiplication of the pa...
متن کاملCCR5 Is Essential for NK Cell Trafficking and Host Survival following Toxoplasma gondii Infection
The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate immune response into an acquired response. We analyzed the host response of mice deficient in the chemokine receptor CCR5 following infection with the intracellular protozoan pa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Research Journal of Parasitology
سال: 2011
ISSN: 1816-4943
DOI: 10.3923/jp.2011.60.73